Recombinant RAGE (Receptor for advanced glycation endproducts), Human, AF

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Recombinant RAGE (Receptor for advanced glycation endproducts), Human, AF
SDS- PAGE analysis of recombinant human RAGE
Recombinant RAGE (Receptor for advanced glycation endproducts), Human, AF
Recombinant RAGE (Receptor for advanced glycation endproducts), Human, AF
Recombinant RAGE (Receptor for advanced glycation endproducts), Human, AF
Recombinant RAGE (Receptor for advanced glycation endproducts), Human, AF
Recombinant RAGE (Receptor for advanced glycation endproducts), Human, AF
Recombinant RAGE (Receptor for advanced glycation endproducts), Human, AF
Recombinant RAGE (Receptor for advanced glycation endproducts), Human, AF
Recombinant RAGE (Receptor for advanced glycation endproducts), Human, AF
Recombinant RAGE (Receptor for advanced glycation endproducts), Human, AF
Recombinant RAGE (Receptor for advanced glycation endproducts), Human, AF
Recombinant RAGE (Receptor for advanced glycation endproducts), Human, AF

产品简介

产品简介

Catalog No.

PY2264

Source

Human Cytokines

UniProt ID

Reactivity

Testing in process

Application

Cell culture, Elisa

Calculated Mol Weight

31 kDa

Observed Mol Weight

40 kDa

Recommended Dilution

It is recommended to reconstitute the lyophilized protein in sterile H2O to a concentration not less than 100 μg/mL and incubate the stock solution for at least 20 min to ensure sufficient re-dissolved.

Alternative Names

advanced glycosylation end-product specific receptor, AGER, SCARJ1

Host

Escherichia coli

Isotype

Clonality

Modification

His-tag at the C-terminus

Immunogen

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Purification

>98% as determined by SDS-PAGE. Ni-NTA chromatography

Concentration

Buffer System

<0.1 EU per 1 μg of the protein by the LAL method. The protein was lyophilized from a 0.2 µm filtered solution containing 1X PBS, pH 8.0.

Storage Condition

Lyophilized protein should be stored at -20°C for 1 year. Upon reconstitution, store at 2°C to 8°C for up to 1 week. Further dilute in a buffer containing a carrier protein or stabilizer (e.g. 0.1% BSA, 10%FBS, 5%HSA or 5% trehalose solution), protein aliquots should be stored at -20°C or -80°C for 3-6 months.

Description

RAGE (receptor for advanced glycation endproducts), also called AGER, is a 35 kilodalton transmembrane receptor of the immunoglobulin super family, as a signal transduction receptor which binds advanced glycation endproducts, certain members of the S1/calgranulin family of proteins, high mobility group box 1 (HMGB1), advanced oxidation protein products, and amyloid (beta-sheet fibrils). Initial studies investigating the role of RAGE in renal dysfunction focused on diabetes, neurodegenerative disorders, and inflammatory responses. However, RAGE also has roles in the pathogenesis of renal disorders that are not associated with diabetes, such as obesity-related glomerulopathy, doxorubicin-induced nephropathy, hypertensive nephropathy, lupus nephritis, renal amyloidosis, and ischemic renal injuries. RAGE represents an important factor in innate immunity against pathogens, but it also interacts with endogenous ligands, resulting in chronic inflammation. RAGE signaling has been implicated in multiple human illnesses, including atherosclerosis, arthritis, Alzheimer's disease, atherosclerosis and aging associated diseases.

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PY2264

规格:

5μg, 20μg, 100μg, 500μg, 1mg

价格:

¥800/5μg, ¥2000/20μg, ¥6000/100μg, ¥18000/500μg, ¥26000/1mg

货期:

3-4天

订购信息:

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