Recombinant IL-37 (Interleukin-37), Human, AF
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Recombinant IL-37 (Interleukin-37), Human, AF
SDS- PAGE analysis of recombinant human IL-37
Recombinant IL-37 (Interleukin-37), Human, AF
Recombinant IL-37 (Interleukin-37), Human, AF
Recombinant IL-37 (Interleukin-37), Human, AF
Recombinant IL-37 (Interleukin-37), Human, AF
Recombinant IL-37 (Interleukin-37), Human, AF
Recombinant IL-37 (Interleukin-37), Human, AF
Recombinant IL-37 (Interleukin-37), Human, AF
Recombinant IL-37 (Interleukin-37), Human, AF
Recombinant IL-37 (Interleukin-37), Human, AF
Recombinant IL-37 (Interleukin-37), Human, AF
Recombinant IL-37 (Interleukin-37), Human, AF

产品简介

产品简介

Catalog No.

PY2243

Source

Human Cytokines

UniProt ID

Q9NZH6

Reactivity

Measure by its ability to induce IL-8 secretion in human PBMCs. The ED50 for this effect is <0.9 μg/mL.

Application

Cell culture, Elisa

Calculated Mol Weight

19 kDa

Observed Mol Weight

22 kDa

Recommended Dilution

It is recommended to reconstitute the lyophilized protein in sterile H2O to a concentration not less than 100 μg/mL and incubate the stock solution for at least 20 min to ensure sufficient re-dissolved.

Alternative Names

IL-1F7, IL-1ζ (zeta), IL-1H4, FIL1, FIL1Z

Host

Escherichia coli

Isotype

Clonality

Modification

His-tag at the C-terminus

Immunogen

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Purification

>95% as determined by SDS-PAGE. Ni-NTA chromatography.

Concentration

Buffer System

<0.1 EU per 1 μg of the protein by the LAL method. The protein was lyophilized from a 0.2 µm filtered solution containing 1X PBS, pH 8.0.

Storage Condition

Lyophilized protein should be stored at -20°C for 1 year. Upon reconstitution, store at 2°C to 8°C for up to 1 week. Further dilute in a buffer containing a carrier protein or stabilizer (e.g. 0.1% BSA, 10%FBS, 5%HSA or 5% trehalose solution), protein aliquots should be stored at -20°C or -80°C for 3-6 months.

Description

Decreasing synthesis of IL-37 in PBMCs will cause increasing production of pro-inflammatory cytokines such as IL-1 alpha, IL-1 beta, IL-6 and TNF- alpha. The IL-37 work as an innate inflammatory inhibitor is also proved by its high expression in synovial tissue from rheumatoid arthritis patients. Full length IL-37 locates mainly in the cytoplasm, and it can translocate to the nucleus after activation through cleavage by CASP1, then exerts its activity by directly interacting with SMAD3.

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PY2243

规格：

5μg, 20μg, 100μg, 500μg, 1mg

价格：

¥800/5μg, ¥2000/20μg, ¥6000/100μg, ¥18000/500μg, ¥26000/1mg

货期：

3-4天

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