CD30L is a member of the TNF superfamily, and is a type-II membrane-associated glycoprotein. It is primarily expressed on certain B cells, T cells, and monocytes. In lymphomas and various chronically inflamed tissues, CD30L can specifically bind to CD30 (receptor), which is expressed on activated, but not resting, B and T cells. CD30L can interact with CD30 to start a signaling cascade that can finally lead to the activation of NF-κB. CD30L/CD30 signaling applies pleiotropic effects on normal cells, for example: cell death, differentiation, and cell division. CD30L/CD30 signaling can also affect some kinds of diseases, like Hodgkin’s lymphoma, allergic inflammation, diabetes and mycobacterial infection.