Recombinant APRIL (A proliferation-inducing ligand), Human, AF
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Recombinant APRIL (A proliferation-inducing ligand), Human, AF
SDS- PAGE analysis of recombinant human APRIL
Recombinant APRIL (A proliferation-inducing ligand), Human, AF
Recombinant APRIL (A proliferation-inducing ligand), Human, AF
Recombinant APRIL (A proliferation-inducing ligand), Human, AF
Recombinant APRIL (A proliferation-inducing ligand), Human, AF
Recombinant APRIL (A proliferation-inducing ligand), Human, AF
Recombinant APRIL (A proliferation-inducing ligand), Human, AF
Recombinant APRIL (A proliferation-inducing ligand), Human, AF
Recombinant APRIL (A proliferation-inducing ligand), Human, AF
Recombinant APRIL (A proliferation-inducing ligand), Human, AF
Recombinant APRIL (A proliferation-inducing ligand), Human, AF
Recombinant APRIL (A proliferation-inducing ligand), Human, AF

产品简介

产品简介

Catalog No.

PY2105

Source

Human Cytokines

UniProt ID

O75888

Reactivity

Measured by its ability to induce cell death in Jurkat cells. The ED50 for this effect is 2.6-4.0 μg/mL.

Application

Cell culture, Elisa

Calculated Mol Weight

17 kDa

Observed Mol Weight

18 kDa

Recommended Dilution

It is recommended to reconstitute the lyophilized protein in sterile H2O to a concentration not less than 100 μg/mL and incubate the stock solution for at least 20 min to ensure sufficient re-dissolved.

Alternative Names

TNFSF13, CD256, TALL-2, TALL2, TNLG7B, TRDL-1, UNQ383/PRO715, ZTNF2

Host

Escherichia coli

Isotype

Clonality

Modification

His-tag at the C-terminus

Immunogen

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Purification

>98% as determined by SDS-PAGE. Ni-NTA chromatography

Concentration

Buffer System

<0.1 EU per 1 μg of the protein by the LAL method. The protein was lyophilized from a 0.2 µm filtered solution containing 0.1% sarkosyl in 1X PBS, pH 8.0.

Storage Condition

Lyophilized protein should be stored at -20°C for 1 year. Upon reconstitution, store at 2°C to 8°C for up to 1 week. Further dilute in a buffer containing a carrier protein or stabilizer (e.g. 0.1% BSA, 10%FBS, 5%HSA or 5% trehalose solution), protein aliquots should be stored at -20°C or -80°C for 3-6 months.

Description

APRIL (A PRoliferation-Inducing Ligand) is a member of the tumor necrosis factor family. APRIL shows high levels of expression in tumors of different origin and low level of expression in normal cells. APRIL shares two TNF receptor family members, TACI and BCMA (or another TNF homolog, BlyS/BAFF) have been reported to play a role in autoimmune disease and cancer. The protein encoded by this gene is a member of the tumor necrosis factor ligand (TNF) ligand family. This protein is a ligand for TNFRSF17/BCMA, a member of the TNF receptor family. This protein and its receptor are both found to be important for B cell development. In vivo experiments suggest an important role for APRIL in the long-term survival of plasma cells in the bone marrow. Mice deficient in APRIL have normal immune system development. However, APRIL-deficient mice have also been reported to possess a reduced ability to support plasma cell survival. In vitro experiments suggested that this protein may be able to induce apoptosis through its interaction with other TNF receptor family proteins such as TNFRSF6/FAS and TNFRSF14/HVEM. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

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PY2105

规格：

5μg, 20μg, 100μg, 500μg, 1mg

价格：

¥800/5μg, ¥2000/20μg, ¥6000/100μg, ¥18000/500μg, ¥26000/1mg

货期：

3-4天

订购信息：

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