CDKN2A Ab
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CDKN2A Ab
All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.
CDKN2A Ab
All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.
CDKN2A Ab
All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.
CDKN2A Ab
Western blot analysis of CDKN2A/p14ARF expression in PC3 cell lysate.
CDKN2A Ab
Immunofluorescent analysis using the Antibody at 1:50 dilution.
CDKN2A Ab
CDKN2A Ab
CDKN2A Ab
CDKN2A Ab
CDKN2A Ab
CDKN2A Ab
CDKN2A Ab

产品简介

产品简介

Catalog No.

CY8312

Source

Recombinant Rabbit mAb

UniProt ID

Q8N726

Reactivity

Human

Application

WB;ICC/IF;IP;FC

Calculated Mol Weight

14 kDa

Observed Mol Weight

14 kDa

Recommended Dilution

WB 1:1000-1:2000

ICC/IF 1:50-1:200

IP 1:20-1:50

FC 1:20-1:100

Alternative Names

ARF; CDK4I; CDKN2; CDKN2A; CMM2; INK4; INK4a; MLM; MTS1; p14; p14ARF;

Host

Rabbit

Isotype

Rabbit IgG

Clonality

Monoclonal

Modification

Unmodified

Immunogen

A synthesized peptide derived from human CDKN2A

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Purification

Affinity-chromatography

Concentration

Buffer System

Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.

Storage Condition

Store at +4°C for short term. Store at -20°C for long term. Avoid freeze/thaw cycle.

Description

Capable of inducing cell cycle arrest in G1 and G2 phases. Acts as a tumor suppressor. Binds to MDM2 and blocks its nucleocytoplasmic shuttling by sequestering it in the nucleolus. This inhibits the oncogenic action of MDM2 by blocking MDM2-induced degradation of p53 and enhancing p53-dependent transactivation and apoptosis. Also induces G2 arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 complexes.

引用文献

引用文献

Porcine circovirus type 2 infection promotes the SUMOylation of nucleophosmin-1 to facilitate the viral circular single-stranded DNA replication

期刊名称：

PLoS Pathogens

PMID：

38394330

影响因子：

5.5

应用范围：

WB

检测物种：

Pig

发表时间：

2024-02-23

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CY8312

规格：

20μl, 50μl, 100μl

价格：

¥600/20μl, ¥1100/50μl, ¥2000/100μl

货期：

现货

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