PDK2 Ab
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PDK2 Ab
Western blot analysis of PDK2 expression in (1) SH-SY5Y cell lysate; (2) Mouse heart lysate.
PDK2 Ab
PDK2 Ab
PDK2 Ab
PDK2 Ab
PDK2 Ab
PDK2 Ab
PDK2 Ab
PDK2 Ab
PDK2 Ab
PDK2 Ab
PDK2 Ab

产品简介

产品简介

Catalog No.

CY7193

Source

Recombinant Rabbit mAb

UniProt ID

Q15119

Reactivity

Human;Mouse;Rat

Application

WB;IHC;ICC/IF;IHF;IP;FC

Calculated Mol Weight

46 kDa

Observed Mol Weight

46 kDa

Recommended Dilution

WB 1:1000-1:2000

IHC 1:100-1:200

ICC/IF 1:50-1:200

IHF 1:50-1:200

IP 1:20-1:50

FC 1:20-1:100

Alternative Names

PDHK2; PDK2;

Host

Rabbit

Isotype

Rabbit IgG

Clonality

Monoclonal

Modification

Unmodified

Immunogen

A synthesized peptide derived from human PDK2

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Purification

Affinity-chromatography

Concentration

Buffer System

Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.

Storage Condition

Store at +4°C for short term. Store at -20°C for long term. Avoid freeze/thaw cycle.

Description

Kinase that plays a key role in the regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism. Mediates cellular responses to insulin.

引用文献

引用文献

Inhibition of pyruvate dehydrogenase kinase improves carbohydrate utilization in Nile tilapia by regulating PDK2/4-PDHE1α axis and insulin sensitivity

期刊名称：

Animal Nutrition

PMID：

36016966

影响因子：

5.285

应用范围：

WB

检测物种：

Fish

发表时间：

2022-06-24
Double-edged effect of sodium citrate in Nile tilapia (Oreochromis niloticus): promoting lipid and protein deposition vs. causing hyperglycemia and insulin resistance

期刊名称：

Animal Nutrition

PMID：

37635932

影响因子：

6.3

应用范围：

WB

检测物种：

Fish

发表时间：

2023-06-29

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CY7193

规格：

20μl, 50μl, 100μl

价格：

¥600/20μl, ¥1100/50μl, ¥2000/100μl

货期：

现货

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