p-MLKL (S358) Ab
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p-MLKL (S358) Ab
All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.
p-MLKL (S358) Ab
Western blot analysis of Phospho-MLKL (S358) expression in (1) HT-29 cell lysate; (2) HT-29 cell lysate treated with TNF alpha+ Smac mimetic+ z-VAD.
p-MLKL (S358) Ab
p-MLKL (S358) Ab
p-MLKL (S358) Ab
p-MLKL (S358) Ab
p-MLKL (S358) Ab
p-MLKL (S358) Ab
p-MLKL (S358) Ab
p-MLKL (S358) Ab
p-MLKL (S358) Ab
p-MLKL (S358) Ab

产品简介

产品简介

Catalog No.

CY7146

Source

Recombinant Rabbit mAb

UniProt ID

Q8NB16

Reactivity

Human

Application

WB;IHC

Calculated Mol Weight

54 kDa

Observed Mol Weight

54 kDa

Recommended Dilution

WB 1:1000-1:2000

IHC 1:100-1:200

Alternative Names

hMLKL; Mlkl;

Host

Rabbit

Isotype

Rabbit IgG

Clonality

Monoclonal

Modification

Phosphorylated

Immunogen

A synthesized peptide derived from human MLKL around the phosphorylation site of S358

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Purification

Affinity-chromatography

Concentration

Buffer System

Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.

Storage Condition

Store at +4°C for short term. Store at -20°C for long term. Avoid freeze/thaw cycle.

Description

Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process.Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage.

引用文献

引用文献

Eupalinolide B inhibits hepatic carcinoma by inducing ferroptosis and ROS-ER-JNK pathway

期刊名称：

ACTA BIOCHIMICA ET BIOPHYSICA SINICA

PMID：

35866605

影响因子：

3.511

应用范围：

WB

检测物种：

发表时间：

2022-07-25
Eupalinolide A induces autophagy via the ROS/ERK signaling pathway in hepatocellular carcinoma cells in vitro and in vivo

期刊名称：

INTERNATIONAL JOURNAL OF ONCOLOGY

PMID：

36111510

影响因子：

5.884

应用范围：

WB

检测物种：

Human

发表时间：

2022-09-15

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CY7146

规格：

20μl, 50μl, 100μl

价格：

¥600/20μl, ¥1100/50μl, ¥2000/100μl

货期：

现货

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