p-Histone H2A.X (S139) Ab - 上海埃必威生物技术有限公司

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p-Histone H2A.X (S139) Ab

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SRSF1 Prevents DNA Damage and Promotes Tumorigenesis through Regulation of DBF4B Pre-mRNA Splicing. -Cell Reports

All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.

Immunohistochemical analysis of paraffin-embedded mouse liver, using Phospho-Histone H2A.X (S139) Antibody.

Immunofluorescent analysis of HeLa cells treated with H2O2, using Phospho-Histone H2A.X (S139) Antibody.

产品简介

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产品简介

Catalog No.

CY6572

Source

Recombinant Rabbit mAb

UniProt ID

P16104

Reactivity

Human;Mouse;Rat

Application

WB;IHC;ICC/IF;IHF;IP

Calculated Mol Weight

15 kDa

Observed Mol Weight

15 kDa

Recommended Dilution

WB 1:1000-1:5000

IHC 1:100-1:200

ICC/IF 1:50-1:200

IHF 1:50-1:200

IP 1:20-1:50

Alternative Names

H2A.X; H2AFX; H2a/x; HIST5-2AX; Histone H2A.X;

Host

Rabbit

Isotype

Rabbit IgG

Clonality

Monoclonal

Modification

Phosphorylated

Immunogen

A synthesized peptide derived from human Histone H2A.X around the phosphorylation site of S139

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Purification

Affinity-chromatography

Concentration

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Buffer System

Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.

Storage Condition

Store at +4°C for short term. Store at -20°C for long term. Avoid freeze/thaw cycle.

Description

Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.

引用文献

SRSF1 Prevents DNA Damage and Promotes Tumorigenesis through Regulation of DBF4B Pre-mRNA Splicing

期刊名称：

Cell Reports

PMID：

29262322

影响因子：

8.282

应用范围：

WB,ICC/IF

检测物种：

Mouse,Human

发表时间：

2017-12-19

Administration of trastuzumab with heart irradiation induced acute cardiotoxicity in mice

期刊名称：

American Journal of Cancer Research

PMID：

32195025

影响因子：

5.177

应用范围：

IHC

检测物种：

Mouse

发表时间：

2020-02-01

AMPK alleviates oxidative stress‑induced premature senescence via inhibition of NF-κB/STAT3 axis-mediated positive feedback loop

期刊名称：

MECHANISMS OF AGEING AND DEVELOPMENT

PMID：

32882228

影响因子：

4.304

应用范围：

检测物种：

Mouse

发表时间：

2020-08-31

Asparaginyl endopeptidase (AEP) regulates myocardial apoptosis in response to radiation exposure via alterations in NRF2 activation

期刊名称：

American Journal of Cancer Research

PMID：

33948354

影响因子：

6.166

应用范围：

ICC/IF

检测物种：

Human,Rat

发表时间：

2021-04-15

Trastuzumab aggravates radiation induced cardiotoxicity in mice

期刊名称：

American Journal of Cancer Research

PMID：

35141025

影响因子：

5.942

应用范围：

ICC/IF

检测物种：

Rat

发表时间：

2022-01-15

β-sitosterol alleviates pulmonary arterial hypertension by altering smooth muscle cell phenotype and DNA damage /cGAS/STING signaling

期刊名称：

PHYTOMEDICINE

PMID：

39265206

影响因子：

6.7

应用范围：

WB,ICC/IF

检测物种：

Rat

发表时间：

2024-09-07

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尾页

CY6572

规格：

20μl, 50μl, 100μl

价格：

¥600/20μl, ¥1100/50μl, ¥2000/100μl

货期：

现货

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