p21 CDKN1A Ab
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p21 CDKN1A Ab
All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.
p21 CDKN1A Ab
Western blot analysis of p21 in (1) MCF-7 cell lysate; (2) HeLa cell lysate. (3) LnCap cell lysate; (4) U87 MG cell lysate.
p21 CDKN1A Ab
Fibulin-3 has anti-tumorigenic activities in cutaneous squamous cell carcinoma. -Journal of Investigative Dermatology
p21 CDKN1A Ab
Immunofluorescent analysis using the Antibody at 1:150 dilution.
p21 CDKN1A Ab
Immunofluorescent analysis of MCF7 cells, using p21 Antibody.
p21 CDKN1A Ab
p21 CDKN1A Ab
p21 CDKN1A Ab
p21 CDKN1A Ab
p21 CDKN1A Ab
p21 CDKN1A Ab
p21 CDKN1A Ab

产品简介

产品简介

Catalog No.

CY5543

Source

Recombinant Rabbit mAb

UniProt ID

P38936

Reactivity

Human;Mouse;Rat

Application

WB;ICC/IF

Calculated Mol Weight

18 kDa

Observed Mol Weight

21 kDa

Recommended Dilution

WB 1:1000-1:2000

ICC/IF 1:50-1:200

Alternative Names

CAP20; CDKN1; CIP1; MDA-6; P21; SDI1; WAF1; p21CIP1

Host

Rabbit

Isotype

Rabbit IgG

Clonality

Monoclonal

Modification

Unmodified

Immunogen

A synthesized peptide derived from human CDKN1A

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Purification

Affinity-chromatography

Concentration

Buffer System

Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.

Storage Condition

Store at +4°C for short term. Store at -20°C for long term. Avoid freeze/thaw cycle.

Description

The tumor suppressor protein p21 Waf1/Cip1 acts as an inhibitor of cell cycle progression. It functions in stoichiometric relationships forming heterotrimeric complexes with cyclins and cyclin-dependent kinases. In association with CDK2 complexes, it serves to inhibit kinase activity and block progression through G1/S. However, p21 may also enhance assembly and activity in complexes of CDK4 or CDK6 and cyclin D.

引用文献

引用文献

EGR1-Mediated Transcription of lncRNA-HNF1A-AS1 Promotes Cell-Cycle Progression in Gastric Cancer

期刊名称：

CANCER RESEARCH

PMID：

30185552

影响因子：

9.13

应用范围：

WB

检测物种：

Human

发表时间：

2018-10-15
Autolysosomal degradation of cytosolic chromatin fragments antagonizes oxidative stress–induced senescence

期刊名称：

JOURNAL OF BIOLOGICAL CHEMISTRY

PMID：

32047109

影响因子：

4.238

应用范围：

WB

检测物种：

Mouse

发表时间：

2020-02-11
Macrophage NCOR1 Deficiency Ameliorates Myocardial Infarction and Neointimal Hyperplasia in Mice

期刊名称：

Journal of the American Heart Association

PMID：

32720575

影响因子：

4.605

应用范围：

WB

检测物种：

Mouse

发表时间：

2020-07-28
AMPK alleviates oxidative stress‑induced premature senescence via inhibition of NF-κB/STAT3 axis-mediated positive feedback loop

期刊名称：

MECHANISMS OF AGEING AND DEVELOPMENT

PMID：

32882228

影响因子：

4.304

应用范围：

WB

检测物种：

Mouse

发表时间：

2020-08-31
E47 upregulates ΔNp63α to promote growth of squamous cell carcinoma

期刊名称：

Cell Death & Disease

PMID：

33833226

影响因子：

8.469

应用范围：

WB,IHC

检测物种：

Human

发表时间：

2021-04-08
CDK-associated Cullin 1 Promotes Cell Proliferation and Inhibits Cell Apoptosis in Human Glioblastoma

期刊名称：

CURRENT CANCER DRUG TARGETS

PMID：

34080964

影响因子：

3.428

应用范围：

WB

检测物种：

Human

发表时间：

2021-11-01

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CY5543

规格：

20μl, 50μl, 100μl

价格：

¥600/20μl, ¥1100/50μl, ¥2000/100μl

货期：

现货

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