SMAD4 Ab
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SMAD4 Ab
Western blot analysis of extracts from HeLa cells, COS-7 cells, HepG2 cells and HUVEC cells, using Smad4 antibody.
SMAD4 Ab
SMAD4 Ab
SMAD4 Ab
SMAD4 Ab
SMAD4 Ab
SMAD4 Ab
SMAD4 Ab
SMAD4 Ab
SMAD4 Ab
SMAD4 Ab
SMAD4 Ab

产品简介

产品简介

Catalog No.

AY4205

Source

Rabbit pAb

UniProt ID

Q13485

Reactivity

Human;Mouse;Rat

Application

WB

Calculated Mol Weight

60 kDa

Observed Mol Weight

60 kDa

Recommended Dilution

WB 1:500-1:1000

Alternative Names

SMAD 4, Mothers against decapentaplegic homolog 4, Mothers against DPP homolog 4, Deletion target in pancreatic carcinoma 4, hSMAD4, DPC4, MADH4

Host

Rabbit

Isotype

Rabbit IgG

Clonality

Polyclonal

Modification

Unmodified

Immunogen

A synthesized peptide derived from human SMAD4

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Purification

Affinity-chromatography

Concentration

Buffer System

Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05%BSA, 0.02% sodium azide and 50% glycerol.

Storage Condition

Store at +4°C for short term. Store at -20°C for long term. Avoid freeze/thaw cycle.

Description

In muscle physiology, plays a central role in the balance between atrophy and hypertrophy. When recruited by MSTN, promotes atrophy response via phosphorylated SMAD2/4. MSTN decrease causes SMAD4 release and subsequent recruitment by the BMP pathway to promote hypertrophy via phosphorylated SMAD1/5/8. Acts synergistically with SMAD1 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions.

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AY4205

规格：

20μl, 50μl, 100μl

价格：

¥600/20μl, ¥1100/50μl, ¥2000/100μl

货期：

次日发货

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