Sestrin 1 Ab
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Sestrin 1 Ab
Western blot analysis of extracts from rat muscle cells, using SESN1 antibody.
Sestrin 1 Ab
Sestrin 1 Ab
Sestrin 1 Ab
Sestrin 1 Ab
Sestrin 1 Ab
Sestrin 1 Ab
Sestrin 1 Ab
Sestrin 1 Ab
Sestrin 1 Ab
Sestrin 1 Ab
Sestrin 1 Ab

产品简介

产品简介

Catalog No.

AY4084

Source

Rabbit pAb

UniProt ID

Q9Y6P5

Reactivity

Human;Mouse

Application

WB;IHC

Calculated Mol Weight

57 kDa

Observed Mol Weight

57 kDa

Recommended Dilution

WB 1:500-1:1000

IHC 1:50-1:100

Alternative Names

Sestrin-1; p53-regulated protein PA26; SESN1

Host

Rabbit

Isotype

Rabbit IgG

Clonality

Polyclonal

Modification

Unmodified

Immunogen

A synthesized peptide derived from human Sestrin 1

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Purification

Affinity-chromatography

Concentration

Buffer System

Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05%BSA, 0.02% sodium azide and 50% glycerol.

Storage Condition

Store at +4°C for short term. Store at -20°C for long term. Avoid freeze/thaw cycle.

Description

Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling. Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway.

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AY4084

规格：

20μl, 50μl, 100μl

价格：

¥600/20μl, ¥1100/50μl, ¥2000/100μl

货期：

次日发货

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