ASC Ab
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ASC Ab
Western blot analysis of extracts from RAW264.7 cells, using ASC antibody.
ASC Ab
ASC Ab
ASC Ab
ASC Ab
ASC Ab
ASC Ab
ASC Ab
ASC Ab
ASC Ab
ASC Ab
ASC Ab

产品简介

产品简介

Catalog No.

AY3812

Source

Rabbit pAb

UniProt ID

Q9ULZ3

Reactivity

Human;Mouse;Rat

Application

WB;IHC

Calculated Mol Weight

22 kDa

Observed Mol Weight

22 kDa

Recommended Dilution

WB 1:500-1:1000

IHC 1:50-1:100

Alternative Names

PYCARD;ASC;CARD5;MGC10332;TMS;TMS-1;TMS1 ;

Host

Rabbit

Isotype

Rabbit IgG

Clonality

Polyclonal

Modification

Unmodified

Immunogen

A synthesized peptide derived from human ASC

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Purification

Affinity-chromatography

Concentration

Buffer System

Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05%BSA, 0.02% sodium azide and 50% glycerol.

Storage Condition

Store at +4°C for short term. Store at -20°C for long term. Avoid freeze/thaw cycle.

Description

Functions as a key mediator in apoptosis and inflammation.Promotes caspase-mediated apoptosis involving predominantly caspase-8 and also caspase-9 in a probable cell type-specific manner.Involved in activation of the mitochondrial apoptotic pathway, promotes caspase-8-dependent proteolytic maturation of BID independently of FADD in certain cell types and also mediates mitochondrial translocation of BAX and activates BAX-dependent apoptosis coupled to activation of caspase-9, -2 and -3.

引用文献

引用文献

Inhibition of vascular neointima hyperplasia by FGF21 associated with FGFR1/Syk/NLRP3 inflammasome pathway in diabetic mice

期刊名称：

ATHEROSCLEROSIS

PMID：

31513948

影响因子：

4.255

应用范围：

WB,ICC/IF,IHC

检测物种：

Mouse

发表时间：

2019-08-29
Protective effects of acarbose against vascular endothelial dysfunction through inhibiting Nox4/NLRP3 inflammasome pathway in diabetic rats

期刊名称：

FREE RADICAL BIOLOGY AND MEDICINE

PMID：

31541678

影响因子：

5.657

应用范围：

WB,ICC/IF

检测物种：

Rat

发表时间：

2019-09-18
NLRP3 inflammasome links vascular senescence to diabetic vascular lesions

期刊名称：

PHARMACOLOGICAL RESEARCH

PMID：

35219871

影响因子：

10.334

应用范围：

ICC/IF,IHC,WB

检测物种：

Mouse

发表时间：

2022-02-24
Angelica Yinzi alleviates 1-chloro-2,4-dinitrobenzene-induced atopic dermatitis by inhibiting activation of NLRP3 inflammasome and down-regulating the MAPKs/NF-kB signaling pathway

期刊名称：

SAUDI PHARMACEUTICAL JOURNAL

PMID：

36387340

影响因子：

4.562

应用范围：

IHC

检测物种：

Mouse

发表时间：

2022-07-19
Sodium tanshinone IIA sulfonate ameliorates neointima by protecting endothelial progenitor cells in diabetic mice

期刊名称：

BMC Cardiovascular Disorders

PMID：

37697234

影响因子：

2.1

应用范围：

WB,ICC/IF,IP

检测物种：

Mouse

发表时间：

2023-09-11

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AY3812

规格：

20μl, 50μl, 100μl

价格：

¥600/20μl, ¥1100/50μl, ¥2000/100μl

货期：

次日发货

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