PMS2 Ab
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PMS2 Ab
Western blot analysis of extracts from HeLa cells, using PMS2 antibody.
PMS2 Ab
PMS2 Ab
PMS2 Ab
PMS2 Ab
PMS2 Ab
PMS2 Ab
PMS2 Ab
PMS2 Ab
PMS2 Ab
PMS2 Ab
PMS2 Ab

产品简介

产品简介

Catalog No.

AY3643

Source

Rabbit pAb

UniProt ID

P54278

Reactivity

Human

Application

WB

Calculated Mol Weight

96 kDa

Observed Mol Weight

85 kDa

Recommended Dilution

WB 1:500-1:1000

Alternative Names

DNA mismatch repair gene; DNA mismatch repair protein PMS2; HNPCC4; PMS1 protein homolog 2; PMS2 postmeiotic segregation increased 2; PMS2 postmeiotic segregation increased 2 (S. cerevisiae)

Host

Rabbit

Isotype

Rabbit IgG

Clonality

Polyclonal

Modification

Unmodified

Immunogen

A synthesized peptide derived from human PMS2

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Purification

Affinity-chromatography

Concentration

Buffer System

Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05%BSA, 0.02% sodium azide and 50% glycerol.

Storage Condition

Store at +4°C for short term. Store at -20°C for long term. Avoid freeze/thaw cycle.

Description

Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected.

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AY3643

规格：

20μl, 50μl, 100μl

价格：

¥600/20μl, ¥1100/50μl, ¥2000/100μl

货期：

次日发货

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