BARD1 Ab
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BARD1 Ab
Western blot analysis of extracts from HeLa cells, using BARD1 antibody.
BARD1 Ab
BARD1 Ab
BARD1 Ab
BARD1 Ab
BARD1 Ab
BARD1 Ab
BARD1 Ab
BARD1 Ab
BARD1 Ab
BARD1 Ab
BARD1 Ab

产品简介

产品简介

Catalog No.

AY0947

Source

Rabbit pAb

UniProt ID

Q99728

Reactivity

Human

Application

WB

Calculated Mol Weight

87 kDa

Observed Mol Weight

81 kDa

Recommended Dilution

WB 1:500-1:1000

Alternative Names

BRCA1-associated RING domain protein 1, BARD-1, BARD1

Host

Rabbit

Isotype

Rabbit IgG

Clonality

Polyclonal

Modification

Unmodified

Immunogen

A synthesized peptide derived from human BARD1

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Purification

Affinity-chromatography

Concentration

Buffer System

Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05%BSA, 0.02% sodium azide and 50% glycerol.

Storage Condition

Store at +4°C for short term. Store at -20°C for long term. Avoid freeze/thaw cycle.

Description

E3 ubiquitin-protein ligase. The BRCA1-BARD1 heterodimer specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Plays a central role in the control of the cell cycle in response to DNA damage. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Also forms a heterodimer with CSTF1/CSTF-50 to modulate mRNA processing and RNAP II stability by inhibiting pre-mRNA 3' cleavage.

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AY0947

规格：

20μl, 50μl, 100μl

价格：

¥600/20μl, ¥1100/50μl, ¥2000/100μl

货期：

次日发货

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