p-BLM (T99) Ab
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p-BLM (T99) Ab
Western blot analysis of extracts from HepG2 cells, using Bloom Syndrome Protein (Phospho-Thr99) antibody.
p-BLM (T99) Ab
Immunohistochemistry analysis of paraffin-embedded human heart tissue, using Bloom Syndrome Protein (Phospho-Thr99) antibody.
p-BLM (T99) Ab
Immunofluorescence analysis of HepG2 cells, Bloom Syndrome Protein (Phospho-Thr99) antibody.
p-BLM (T99) Ab
p-BLM (T99) Ab
p-BLM (T99) Ab
p-BLM (T99) Ab
p-BLM (T99) Ab
p-BLM (T99) Ab
p-BLM (T99) Ab
p-BLM (T99) Ab
p-BLM (T99) Ab

产品简介

产品简介

Catalog No.

AY0537

Source

Rabbit pAb

UniProt ID

P54132

Reactivity

Human

Application

WB;IHC;ICC/IF;IHF

Calculated Mol Weight

159 kDa

Observed Mol Weight

159 kDa

Recommended Dilution

WB 1:500-1:1000

IHC 1:50-1:100

ICC/IF 1:50-1:200

IHF 1:50-1:100

Alternative Names

Bloom's syndrome protein, DNA helicase, RecQ-like, type 2, EC 3.6.1.-, RECQ2, RECQL3, RecQ protein-like 3

Host

Rabbit

Isotype

Rabbit IgG

Clonality

Polyclonal

Modification

Phosphorylated

Immunogen

A synthesized peptide derived from human BLM around the phosphorylation site of T99

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Purification

Affinity-chromatography

Concentration

Buffer System

Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05%BSA, 0.02% sodium azide and 50% glycerol.

Storage Condition

Store at +4°C for short term. Store at -20°C for long term. Avoid freeze/thaw cycle.

Description

ATP-dependent DNA helicase that unwinds single- and double-stranded DNA in a 3'-5' direction. Participates in DNA replication and repair. Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA. Negatively regulates sister chromatid exchange (SCE). Stimulates DNA 4-way junction branch migration and DNA Holliday junction dissolution. Binds single-stranded DNA (ssDNA), forked duplex DNA and DNA Holliday junction. Recruited by the KHDC3L-OOEP scaffold to DNA replication forks where it is retained by TRIM25 ubiquitination, it thereby promotes the restart of stalled replication forks.

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AY0537

规格：

20μl, 50μl, 100μl

价格：

¥600/20μl, ¥1100/50μl, ¥2000/100μl

货期：

次日发货

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