p-beta Arrestin 1 (S412) Ab - 上海埃必威生物技术有限公司

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p-beta Arrestin 1 (S412) Ab

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Western blot analysis of extracts from COS7 cells, treated with Etoposide (25uM, 60mins), using Arrestin 1 (Phospho-Ser412) antibody.

Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue using Arrestin 1 (Phospho-Ser412) antibody.

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产品简介

Catalog No.

AY0493

Source

Rabbit pAb

UniProt ID

P49407

Reactivity

Human

Application

WB;IHC

Calculated Mol Weight

47 kDa

Observed Mol Weight

47 kDa

Recommended Dilution

WB 1:500-1:1000

IHC 1:50-1:100

Alternative Names

ARR1, arrestin 2, arrestin beta 1, beta-arrestin-1

Host

Rabbit

Isotype

Rabbit IgG

Clonality

Polyclonal

Modification

Phosphorylated

Immunogen

A synthesized peptide derived from human beta Arrestin 1 around the phosphorylation site of S412

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Purification

Affinity-chromatography

Concentration

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Buffer System

Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05%BSA, 0.02% sodium azide and 50% glycerol.

Storage Condition

Store at +4°C for short term. Store at -20°C for long term. Avoid freeze/thaw cycle.

Description

Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation.

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AY0493

规格：

20μl, 50μl, 100μl

价格：

¥600/20μl, ¥1100/50μl, ¥2000/100μl

货期：

次日发货

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