Cleaved-Notch 1 (V1754) Ab
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Cleaved-Notch 1 (V1754) Ab
Western blot analysis of extracts from NIH/3T3 cells, treated with etoposide (25μM, 1hour), using Notch 1 (cleaved-Val1754) antibody.
Cleaved-Notch 1 (V1754) Ab
Immunohistochemical analysis of paraffin-embedded human brain tissue, using Notch 1 (cleaved-Val1754) antibody.
Cleaved-Notch 1 (V1754) Ab
Cleaved-Notch 1 (V1754) Ab
Cleaved-Notch 1 (V1754) Ab
Cleaved-Notch 1 (V1754) Ab
Cleaved-Notch 1 (V1754) Ab
Cleaved-Notch 1 (V1754) Ab
Cleaved-Notch 1 (V1754) Ab
Cleaved-Notch 1 (V1754) Ab
Cleaved-Notch 1 (V1754) Ab
Cleaved-Notch 1 (V1754) Ab

产品简介

产品简介

Catalog No.

AY0472

Source

Rabbit pAb

UniProt ID

P46531

Reactivity

Human;Mouse;Rat

Application

WB;IHC

Calculated Mol Weight

86,273 kDa

Observed Mol Weight

109 kDa

Recommended Dilution

WB 1:500-1:1000

IHC 1:50-1:100

Alternative Names

NOTC1, NOTCH1, TAN1, hN1, neurogenic locus notch homolog protein 1, neurogenic locus notch homolog protein 1 precursor, notch (Drosophila) homolog 1 (translocation-associated), notch homolog 1, translocation-associated (Drosophila), translocation-associated notch protein TAN-1

Host

Rabbit

Isotype

Rabbit IgG

Clonality

Polyclonal

Modification

Other

Immunogen

A synthesized peptide derived from human Notch 1

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Purification

Affinity-chromatography

Concentration

Buffer System

Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05%BSA, 0.02% sodium azide and 50% glycerol.

Storage Condition

Store at +4°C for short term. Store at -20°C for long term. Avoid freeze/thaw cycle.

Description

Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting.

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AY0472

规格：

20μl, 50μl, 100μl

价格：

¥600/20μl, ¥1100/50μl, ¥2000/100μl

货期：

次日发货

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