SMAD4 Ab
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SMAD4 Ab
All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.
SMAD4 Ab
All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.
SMAD4 Ab
All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.
SMAD4 Ab
Western blot analysis of SMAD4 expression in (1) SH-SY5Y cell lysate; (2) NIH/3T3 cell lysate.
SMAD4 Ab
Eplerenone Prevents Atrial Fibrosis via the TGF-β Signaling Pathway. -cardiology
SMAD4 Ab
Immunohistochemical analysis of paraffin-embedded human breast cancer, using Smad4 Antibody.
SMAD4 Ab
SMAD4 Ab
SMAD4 Ab
SMAD4 Ab
SMAD4 Ab
SMAD4 Ab

产品简介

产品简介

Catalog No.

CY5014

Source

Recombinant Rabbit mAb

UniProt ID

Q13485

Reactivity

Human;Mouse;Rat

Application

WB;IHC

Calculated Mol Weight

60 kDa

Observed Mol Weight

65 kDa

Recommended Dilution

WB 1:1000-1:2000

IHC 1:100-1:200

Alternative Names

MAD homolog 4; MAD, mothers against decapentaplegic homolog 4; MADH4; Mothers against decapentaplegic homolog 4; DPC4; hSMAD4; JIP;

Host

Rabbit

Isotype

Rabbit IgG

Clonality

Monoclonal

Modification

Unmodified

Immunogen

A synthesized peptide derived from human SMAD4

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Purification

Affinity-chromatography

Concentration

Buffer System

Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.

Storage Condition

Store at +4°C for short term. Store at -20°C for long term. Avoid freeze/thaw cycle.

Description

In muscle physiology, plays a central role in the balance between atrophy and hypertrophy. When recruited by MSTN, promotes atrophy response via phosphorylated SMAD2/4. MSTN decrease causes SMAD4 release and subsequent recruitment by the BMP pathway to promote hypertrophy via phosphorylated SMAD1/5/8. Acts synergistically with SMAD1 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions.

引用文献

引用文献

Eplerenone Prevents Atrial Fibrosis via the TGF-β Signaling Pathway

期刊名称：

CARDIOLOGY

PMID：

28571007

影响因子：

1.742

应用范围：

WB

检测物种：

Mouse

发表时间：

2017-06-02

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CY5014

规格：

20μl, 50μl, 100μl

价格：

¥600/20μl, ¥1100/50μl, ¥2000/100μl

货期：

现货

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