p-AKT1 (S473) Ab - 上海埃必威生物技术有限公司

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p-AKT1 (S473) Ab

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All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.

Western blot analysis on 2 NIH/3T3 cell lysate treated with PDGF using Phospho-Akt(Ser473) Antibody.

Prostaglandin E1 Inhibited Diabetes-Induced Phenotypic Switching of Vascular Smooth Muscle Cells Through Activating Autophagy. -Cellular Physiology and Biochemistry

Fibulin-3 has anti-tumorigenic activities in cutaneous squamous cell carcinoma. -Journal of Investigative Dermatology

Critical role for non‑GAP function of Gαs in RGS1‑mediated promotion of melanoma progression through AKT and ERK phosphorylation. -Oncology Reports

Immunohistochemical analysis of paraffin-embedded human kidney, using Phospho-Akt(Ser473) Antibody.

Immunofluorescent analysis using the Antibody at 1:50 dilution.

Immunofluorescent analysis of NIH/3T3 cells treated with PDGF, using Phospho-Akt(Ser473) Antibody.

产品简介

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产品简介

Catalog No.

CY6569

Source

Recombinant Rabbit mAb

UniProt ID

P31749

Reactivity

Human;Mouse;Rat

Application

WB;IHC;ICC/IF;IHF

Calculated Mol Weight

56 kDa

Observed Mol Weight

60 kDa

Recommended Dilution

WB 1:1000-1:2000

IHC 1:100-1:200

ICC/IF 1:50-1:200

IHF 1:50-1:200

Alternative Names

AKT; AKT1 kinase; C-AKT; PKB; PKB-alpha; Protein kinase B; RAC; RAC-PK-alpha;

Host

Rabbit

Isotype

Rabbit IgG

Clonality

Monoclonal

Modification

Phosphorylated

Immunogen

A synthesized peptide derived from human AKT1 around the phosphorylation site of S473

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Purification

Affinity-chromatography

Concentration

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Buffer System

Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.

Storage Condition

Store at +4°C for short term. Store at -20°C for long term. Avoid freeze/thaw cycle.

Description

An AGC kinase that plays a critical role in controlling the balance between survival and AP0ptosis. Phosphorylated and activated by PDK1 in the PI3 kinase pathway. Mediates survival signals downstream of PI3 kinase and several growth factor receptors by phosphorylating AP0pototic proteins. First found in a mouse transforming retrovirus.

引用文献

A novel Bruton's tyrosine kinase inhibitor JDB175 shows potent efficacy to suppress central nervous system lymphoma

期刊名称：

MedComm

PMID：

37929016

影响因子：

9.9

应用范围：

检测物种：

Human

发表时间：

2023-11-04

Isoliquiritigenin Inhibits the Growth of Colorectal Cancer Cells through the ESR2/PI3K/AKT Signalling Pathway

期刊名称：

Pharmaceuticals

PMID：

38256877

影响因子：

4.6

应用范围：

检测物种：

Human

发表时间：

2023-12-27

Bioactive compounds from Dichloromethane extract of Artemisia rupestris L. alleviates CCl4/ConA-induced acute liver injury by inhibiting PI3K-AKT pathway

期刊名称：

JOURNAL OF ETHNOPHARMACOLOGY

PMID：

38848975

影响因子：

4.8

应用范围：

检测物种：

Mouse

发表时间：

2024-06-06

Metabolomics combined with network pharmacology reveals a role for astragaloside IV in inhibiting enterovirus 71 replication via PI3K-AKT signaling

期刊名称：

Journal of Translational Medicine

PMID：

38858642

影响因子：

6.1

应用范围：

检测物种：

Human

发表时间：

2024-06-10

Oncogenic HPV-induced high expression of ESM1 predicts poor prognosis and regulates aerobic glycolysis in cervical cancer

期刊名称：

iScience

PMID：

38947495

影响因子：

4.6

应用范围：

检测物种：

Human

发表时间：

2024-05-27

The resistance to anoikis, mediated by Spp1, and the evasion of immune surveillance facilitate the invasion and metastasis of hepatocellular carcinoma

期刊名称：

APOPTOSIS

PMID：

39066845

影响因子：

6.1

应用范围：

检测物种：

Human

发表时间：

2024-07-27

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CY6569

规格：

20μl, 50μl, 100μl

价格：

¥600/20μl, ¥1100/50μl, ¥2000/100μl

货期：

现货

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